Dnd Is a Critical Specifier of Primordial Germ Cells in the Medaka Fish
Primordial germ cell (PGC) specification occurs early in development.PGC specifiers have been identified in Drosophila, mouse, and human but remained elusive great neck chisels in most animals.Here we identify the RNA-binding protein Dnd as a critical PGC specifier in the medaka fish (Oryzias latipes).Dnd depletion specifically abolished PGCs, and